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Numerical simulation of piezoelectrically agitated surface acoustic waves on microfluidic biochips

机译:微流体生物芯片上压电振动表面声波的数值模拟

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摘要

Microfluidic biochips are biochemical laboratories on the microscale that are used for genotyping and sequencing in genomics, protein pro��?ling in proteomics, and cytometry in cell analysis. There are basically two classes of such biochips: active devices, where the solute transport on a network of channels on the chip surface is realized by external forces, and passive chips, where this is done using a speci��?c design of the geometry of the channel network. Among the active biochips, current interest focuses on devices whose operational principle is based on piezoelectrically driven surface acoustic waves (SAWs) generated by interdigital transducers placed on the chip surface. In this paper, we are concerned with the numerical simulation of such piezoelectrically agitated SAWs relying on a mathematical model that describes the coupling of the underlying piezoelectric and elastomechanical phenomena. Since the interdigital transducers usually operate at a ��?xed frequency, we focus on the time-harmonic case. Its variational formulation gives rise to a generalized saddle point problem for which a Fredholm alternative is shown to hold true. The discretization of the time-harmonic surface acoustic wave equations is taken care of by continuous, piecewise polynomial ��?nite elements with respect to a nested hierarchy of simplicial triangulations of the computational domain. The resulting algebraic saddle point problems are solved by blockdiagonally preconditioned iterative solvers with preconditioners of BPX-type. Numerical results are given both for a test problem documenting the performance of the iterative solution process and for a realistic SAW device illustrating the properties of SAW propagation on piezoelectric materials.
机译:微流体生物芯片是微生化实验室,用于基因组学的基因分型和测序,蛋白质组学中的蛋白质谱分析以及细胞分析中的细胞计数。这类生物芯片基本上分为两类:主动设备(通过外部力实现芯片表面通道网络上的溶质传输)和被动芯片(使用特定的几何设计完成)渠道网络在有源生物芯片中,当前关注的是其工作原理基于放置在芯片表面上的叉指换能器产生的压电驱动的表面声波(SAW)的设备。在本文中,我们依赖于描述基础压电现象和弹性力学现象耦合的数学模型来研究此类压电搅拌声表面波的数值模拟。由于叉指换能器通常以固定频率工作,因此我们将重点放在时谐情况下。它的变式提出了一个广义的鞍点问题,对于该问题,弗雷德霍尔姆替代方案被证明是正确的。时谐表面声波方程的离散化是通过连续的分段多项式有限元素来完成的,该元素相对于计​​算域的简单三角剖分的嵌套层次结构。由此产生的代数鞍点问题可以通过使用BPX类型的预处理器的对角线预处理的迭代求解器来解决。既给出了证明迭代求解过程性能的测试问题,又给出了说明SAW在压电材料上传播特性的实际SAW设备的数值结果。

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